Dr. Verma is intrigued with the conundrum that while DNA replication and repair are essential for viability, cancer cells with defects in these pathways evolve mechanisms to ensure rapid proliferation. Unraveling this mystery offers possibilities to understand mechanisms that lead to genomic instability and identify vulnerabilities that can catalyze the development of improved therapeutic regimens.
Dr. Verma will address three questions:
1. What dictates cellular responses to chemotherapy targeting DNA repair pathways?
2. How do cancer cells deal with roadblocks to replication
3. What are the endogenous DNA lesions in BRCA-mutant cancer cells?